Please don't laugh, I am really truly clueless at this

If I see someone I'd like to meet in another part of a room, should I try and think of a pretext for moving there? Or should I just go right up to them and talk to them? How do I start a conversation from here that isn't awkward and pointless? Is this whole approach totally wrong? How do I keep from getting petrified in these situations?

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I want to know everything
I want to be everywhere
I want to fuck everyone in the world
I want to do something that matters