Personally, I want to know:
Do Deeper Principles Underlie Quantum Uncertainty and Nonlocality?
What powers quasars?
How do proteins find their partners?
....

Ok....I want to know them all. It makes me realize how little we understand, and how personally ignorant I am.

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“Sometimes I think we're alone. Sometimes I think we're not. In either case, the thought is staggering.” - Buckminster Fuller

"A man talking sense to himself is no madder than a man talking nonsense not to himself." - Guildenstern, “Rosencrantz and Guildenstern are Dead”