I don't understand what the point is in even asking this question!

A woman would never ask what to do if her husband's best friend hit on her, as the answer is so obvious. She'd tell him to fuck off in no uncertain terms, and gently try to steer her husband towards more loyal friends.

Are you asking this question because you are flattered by her attention? The woman's a creep with no respect for herself, your wife, your relationship or her relationship with her supposed 'best friend' - even if you were in the market for being unfaithful (which I'm assuming you're not, otherwise why would you bother being married?) would you really want to be with a woman like that?!

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"Time flies like an arrow -
Fruit flies like a banana"

M Y - N A U G H T Y - P I C T U R E S ! !