I have tried almost everything.
The down side of having a busy sex life is the clean up after. This is in no small part the reason I do lots of hotel rondezvous. (By the way I am currently trying to remove a mix of spermacide, peanut butter and cum from a older pre- fabric treatment sofa, any suggestions?)
By the way, the spray on fabric treatments applied to a mattress help with post sex clean up too, but not all can be slept on for some reason (check the label)
I have tried Fabreez (does wonders for odors, stain removal was not that good) and even some commercial mattress cleaning agents along with vacuuming.
I have been through 3 mattresses in 5 years due to stains that wouldn't come out. I once even tried a waterbed!! (just wipe up after, but you still have to wash the mattress cover)
For a regular mattress a hotel grade mattress cover is best, but it does add to the laundry load. Also keeping a stock of nice soft clean large fluffy towels next to the bed helps a LOT.

Wanda

__________________
"I wondered, am I a lesbian, am I straight, or bisexual? Then I realized that I am just a slut.
So where's MY parade?"

---Margaret Cho